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IL-4R/CD124 (Phospho-Tyr497) Colorimetric Cell-Based ELISA Kit

The IL-4R/CD124 (Phospho-Tyr497) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IL-4R/CD124 (Phospho-Tyr497) protein expression profile in cells. The kit can be used for measuring the relative amounts of IL-4R/CD124 (Phospho-Tyr497) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IL-4R/CD124 (Phospho-Tyr497) .

Product Specifications

Synonyms

582J2.1; CD124 antigen; IL-4R-alpha; IL4RA; Interleukin-4 receptor alpha chain precursor

Gene Name

IL4R

UniProt

P24394

Reactivity

Human, Mouse

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

Molecular Weight

89658 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Interleukin-4 receptor subunit alpha

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Frequently Asked Questions

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