HnRNP K (Phospho-Ser284) Colorimetric Cell-Based ELISA Kit

65 kDa phosphoprotein; CSBP; DC-stretch binding protein; Heterogeneous nuclear ribonucleoprotein K; hnRNP-K; HNRNPK; HNRPK; Transformation upregulated nuclear protein; TUNP

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly (C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly (C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity) . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Recruited to p53/TP53- responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036) . In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702) .