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HnRNP C1/2 (Phospho-Ser260) Colorimetric Cell-Based ELISA Kit

The hnRNP C1/2 (Phospho-Ser260) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor hnRNP C1/2 (Phospho-Ser260) protein expression profile in cells. The kit can be used for measuring the relative amounts of hnRNP C1/2 (Phospho-Ser260) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on hnRNP C1/2 (Phospho-Ser260) .

Product Specifications

Synonyms

Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/hnRNP C2; HNRNPC; HNRPC

Gene Name

HNRNPC

UniProt

P07910

Reactivity

Human, Mouse, Rat

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621) . Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621) . Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621) . May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6- methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm (6) A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671) .

Molecular Weight

33670 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC2290

Product MSDS

https://www.bosterbio.com/msds?sku=EKC2290

Other Gene Names

Heterogeneous nuclear ribonucleoproteins C1/C2

Subcellular Location

Nucleus. Component of ribonucleosomes.

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