Epo-R (Phospho-Tyr368) Colorimetric Cell-Based ELISA Kit
The Epo-R (Phospho-Tyr368) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Epo-R (Phospho-Tyr368) protein expression profile in cells. The kit can be used for measuring the relative amounts of Epo-R (Phospho-Tyr368) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Epo-R (Phospho-Tyr368) .
Product Specifications
Synonyms
EPO-R; EPOR; Erythropoietin receptor precursor
Gene Name
EPOR
UniProt
P19235
Reactivity
Human, Mouse, Rat
Tissue Specificity
Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early- stage erythroid progenitor cells.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.
Molecular Weight
55065 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Erythropoietin receptor
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
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