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PTP1B (Phospho-Ser50) Colorimetric Cell-Based ELISA Kit

The PTP1B (Phospho-Ser50) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PTP1B (Phospho-Ser50) protein expression profile in cells. The kit can be used for measuring the relative amounts of PTP1B (Phospho-Ser50) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PTP1B (Phospho-Ser50) .

Product Specifications

Synonyms

CPTP1; Protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase, non-receptor type 1; PTN1; PTP-1B; PTP-HA2; PTPN1

Gene Name

PTPN1

UniProt

P18031

Reactivity

Human, Mouse, Rat

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Molecular Weight

49967 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 1

Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane.

Frequently Asked Questions

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