BCL-XL (Phospho-Thr47) Colorimetric Cell-Based ELISA Kit
The BCL-XL (Phospho-Thr47) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor BCL-XL (Phospho-Thr47) protein expression profile in cells. The kit can be used for measuring the relative amounts of BCL-XL (Phospho-Thr47) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on BCL-XL (Phospho-Thr47) .
Product Specifications
Synonyms
Apoptosis regulator Bcl-X; Bcl-2-like 1 protein; BCL2L; BCL2L1; BCLX; BCLXL; BLC2L
Gene Name
BCL2L1
UniProt
Q07817
Reactivity
Human, Mouse, Rat
Tissue Specificity
Bcl-X (S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X (L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Molecular Weight
26049 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Bcl-2-like protein 1
Subcellular Location
Isoform Bcl-X (L) : Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity) . Localizes to the centrosome when phosphorylated at Ser-49.
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