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PEA-15 (Phospho-Ser104) Colorimetric Cell-Based ELISA Kit

The PEA-15 (Phospho-Ser104) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PEA-15 (Phospho-Ser104) protein expression profile in cells. The kit can be used for measuring the relative amounts of PEA-15 (Phospho-Ser104) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PEA-15 (Phospho-Ser104) .

Product Specifications

Synonyms

Astrocytic phosphoprotein PEA-15; PE15; PEA15; PED; Phosphoprotein enriched in diabetes

Gene Name

PEA15

UniProt

Q15121

Reactivity

Human, Mouse, Rat

Tissue Specificity

Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity) . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Molecular Weight

15040 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Astrocytic phosphoprotein PEA-15

Subcellular Location

Cytoplasm. Associated with microtubules.

Frequently Asked Questions

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