Tuberin/TSC2 (Phospho-Ser939) Colorimetric Cell-Based ELISA Kit

The Tuberin/TSC2 (Phospho-Ser939) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Tuberin/TSC2 (Phospho-Ser939) protein expression profile in cells. The kit can be used for measuring the relative amounts of Tuberin/TSC2 (Phospho-Ser939) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Tuberin/TSC2 (Phospho-Ser939) .

Product Specifications

Synonyms

TSC2; tuberous sclerosis 2 gene; Tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein

Gene Name

TSC2

UniProt

P49815

Reactivity

Human, Mouse, Rat

Tissue Specificity

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.