Progesterone Receptor (Phospho-Ser400) Colorimetric Cell-Based ELISA Kit

The Progesterone Receptor (Phospho-Ser400) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Progesterone Receptor (Phospho-Ser400) protein expression profile in cells. The kit can be used for measuring the relative amounts of Progesterone Receptor (Phospho-Ser400) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Progesterone Receptor (Phospho-Ser400) .

Product Specifications

Synonyms

NR3C3; nuclear receptor 3C3; PGR; PRGR; PR

Gene Name

PGR

UniProt

P06401

Reactivity

Human

Tissue Specificity

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.

Molecular Weight

98981 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Progesterone receptor

Subcellular Location

Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.