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FADD (Phospho-Ser194) Colorimetric Cell-Based ELISA Kit

The FADD (Phospho-Ser194) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FADD (Phospho-Ser194) protein expression profile in cells. The kit can be used for measuring the relative amounts of FADD (Phospho-Ser194) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FADD (Phospho-Ser194) .

Product Specifications

Synonyms

FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; MORT1

Gene Name

FADD

UniProt

Q13158

Reactivity

Human

Tissue Specificity

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Molecular Weight

23279 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

FAS-associated death domain protein

Frequently Asked Questions

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