PLCG1 (Phospho-Tyr783) Colorimetric Cell-Based ELISA Kit
The PLCG1 (Phospho-Tyr783) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PLCG1 (Phospho-Tyr783) protein expression profile in cells. The kit can be used for measuring the relative amounts of PLCG1 (Phospho-Tyr783) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PLCG1 (Phospho-Tyr783) .
Product Specifications
Synonyms
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1; PLCG1; PLC1
Gene Name
PLCG1
UniProt
P19174
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) . Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Molecular Weight
148532 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Subcellular Location
Cell projection, lamellipodium. Cell projection, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
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