CrkII (Phospho-Tyr221) Colorimetric Cell-Based ELISA Kit
The CrkII (Phospho-Tyr221) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CrkII (Phospho-Tyr221) protein expression profile in cells. The kit can be used for measuring the relative amounts of CrkII (Phospho-Tyr221) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CrkII (Phospho-Tyr221) .
Product Specifications
Synonyms
Adapter molecule crk; CRKO; Crk-II; P38; Proto-oncogene C-crk
Gene Name
CRK
UniProt
P46108
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Molecular Weight
33831 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Adapter molecule crk
Subcellular Location
Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion.
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