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CCR5 (Phospho-Ser349) Colorimetric Cell-Based ELISA Kit

The CCR5 (Phospho-Ser349) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CCR5 (Phospho-Ser349) protein expression profile in cells. The kit can be used for measuring the relative amounts of CCR5 (Phospho-Ser349) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CCR5 (Phospho-Ser349) .

Product Specifications

Synonyms

C-C CKR-5; C-C chemokine receptor type 5; CC-CKR-5; CCR-5; CD195 antigen; CHEMR13; CKR5; CMKBR5; HIV-1 fusion co-receptor; MIP-1 alpha receptor

Gene Name

CCR5

UniProt

P51681

Reactivity

Human

Tissue Specificity

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Molecular Weight

40524 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

C-C chemokine receptor type 5

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Frequently Asked Questions

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