Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SHP-2 (Phospho-Tyr580) Colorimetric Cell-Based ELISA Kit

The SHP-2 (Phospho-Tyr580) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 (Phospho-Tyr580) protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 (Phospho-Tyr580) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2 (Phospho-Tyr580) .

Product Specifications

Synonyms

PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase; non-receptor type 11; SH-PTP2; SH-PTP3; SHPTP2

Gene Name

PTPN11

UniProt

Q06124

Reactivity

Human, Mouse, Rat

Tissue Specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .

Molecular Weight

68436 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 11

Subcellular Location

Cytoplasm. Nucleus.

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

KDM5B Recombinant Rabbit Monoclonal Antibody [PSH03-97]
HA722076 100 µL

KDM5B Recombinant Rabbit Monoclonal Antibody [PSH03-97]

Sign In for Pricing
View Details
CYP20A1 Rabbit Polyclonal Antibody
TA370046 100 µL

CYP20A1 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Human SMIM27 activation kit by CRISPRa
GA119089 1 Kit

Human SMIM27 activation kit by CRISPRa

Sign In for Pricing
View Details
PAK2 Mouse Monoclonal Antibody [Clone ID: 7H3-E2-F5]
TA384925 100 µL

PAK2 Mouse Monoclonal Antibody [Clone ID: 7H3-E2-F5]

Sign In for Pricing
View Details
Recombinant MERS-CoV Spike/RBD Protein fragment (RBD, aa 367-606, His Tag), Biotinylated
PKSV030238 20 µg

Recombinant MERS-CoV Spike/RBD Protein fragment (RBD, aa 367-606, His Tag), Biotinylated

Sign In for Pricing
View Details
Recombinant Mouse CCL4
6568 5 µg

Recombinant Mouse CCL4

Sign In for Pricing
View Details