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SHP-2 (Phospho-Tyr580) Colorimetric Cell-Based ELISA Kit

The SHP-2 (Phospho-Tyr580) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 (Phospho-Tyr580) protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 (Phospho-Tyr580) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2 (Phospho-Tyr580) .

Product Specifications

Synonyms

PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase; non-receptor type 11; SH-PTP2; SH-PTP3; SHPTP2

Gene Name

PTPN11

UniProt

Q06124

Reactivity

Human, Mouse, Rat

Tissue Specificity

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .

Molecular Weight

68436 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 11

Subcellular Location

Cytoplasm. Nucleus.

Frequently Asked Questions

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