SHP-1 (Phospho-Tyr536) Colorimetric Cell-Based ELISA Kit

The SHP-1 (Phospho-Tyr536) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-1 (Phospho-Tyr536) protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-1 (Phospho-Tyr536) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-1 (Phospho-Tyr536) .

Product Specifications

Synonyms

70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6; PTP-1C; PTP1C; PTPN6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; Protein-tyrosine phosphatase; non-receptor type 6; SH-PTP1

Gene Name

PTPN6

UniProt

P29350

Reactivity

Human, Mouse, Rat

Tissue Specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Molecular Weight

67561 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC1955

Product MSDS

https://www.bosterbio.com/msds?sku=EKC1955

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 6

Subcellular Location

Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1.