SHP-1 (Phospho-Tyr536) Colorimetric Cell-Based ELISA Kit
The SHP-1 (Phospho-Tyr536) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-1 (Phospho-Tyr536) protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-1 (Phospho-Tyr536) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-1 (Phospho-Tyr536) .
Product Specifications
Synonyms
70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6; PTP-1C; PTP1C; PTPN6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; Protein-tyrosine phosphatase; non-receptor type 6; SH-PTP1
Gene Name
PTPN6
UniProt
P29350
Reactivity
Human, Mouse, Rat
Tissue Specificity
Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Molecular Weight
67561 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein phosphatase non-receptor type 6
Subcellular Location
Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1.
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