CBP Colorimetric Cell-Based ELISA

The CBP Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CBP protein expression profile in cells. The kit can be used for measuring the relative amounts of CBP in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CBP.

Product Specifications

Synonyms

CREB-binding protein;2.3.1.48 ; CREBBP; CBP

Gene Name

CREBBP

UniProt

Q92793

Reactivity

Human, Mouse, Rat

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902) .

Molecular Weight

265351 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC1924

Product MSDS

https://www.bosterbio.com/msds?sku=EKC1924

Other Gene Names

CREB-binding protein

Subcellular Location

Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.

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