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IPMK Colorimetric Cell-Based ELISA

The IPMK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IPMK protein expression profile in cells. The kit can be used for measuring the relative amounts of IPMK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IPMK.

Product Specifications

Synonyms

Inositol polyphosphate multikinase;2.7.1.151; Inositol 1,3,4,6-tetrakisphosphate 5-kinase; IPMK; IMPK

Gene Name

IPMK

UniProt

Q8NFU5

Reactivity

Human, Mouse, Rat

Tissue Specificity

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins (1,4,5) P3) and inositol 1,3,4,6-tetrakisphosphate (Ins (1,3,4,6) P4) (PubMed:12027805, PubMed:12223481) . Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610) .

Molecular Weight

47222 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=EKC1876

Product MSDS

https://www.bosterbio.com/msds?sku=EKC1876

Other Gene Names

Inositol polyphosphate multikinase

Subcellular Location

Nucleus.

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