DOK7 Colorimetric Cell-Based ELISA
The DOK7 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor DOK7 protein expression profile in cells. The kit can be used for measuring the relative amounts of DOK7 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on DOK7.
Product Specifications
Synonyms
Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25
Gene Name
DOK7
UniProt
Q18PE1
Reactivity
Human, Mouse
Tissue Specificity
Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level) .
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Molecular Weight
53097 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Protein Dok-7
Subcellular Location
Cell membrane; Peripheral membrane protein. Cell junction, synapse. Accumulates at neuromuscular junctions.
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