CDK5R1 Colorimetric Cell-Based ELISA
The CDK5R1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CDK5R1 protein expression profile in cells. The kit can be used for measuring the relative amounts of CDK5R1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CDK5R1.
Product Specifications
Synonyms
Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1, p35; p35; Cyclin-dependent kinase 5 activator 1, p25; p25; Tau protein kinase II 23 kDa subunit; p23; CDK5R1; CDK5R, NCK5A
Gene Name
CDK5R1
UniProt
Q15078
Reactivity
Human, Mouse, Rat
Tissue Specificity
Brain and neuron specific.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
P35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Molecular Weight
34060 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Cyclin-dependent kinase 5 activator 1
Subcellular Location
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
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