ZNF147 Colorimetric Cell-Based ELISA

E3 ubiquitin/ISG15 ligase TRIM25;6.3.2.n3 ; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase;2.3.2.27 ; RING-type E3 ubiquitin transferase TRIM25 ; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147; TRIM25; EFP, RNF147, ZNF147

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784) .