DYR1A Colorimetric Cell-Based ELISA

The DYR1A Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor DYR1A protein expression profile in cells. The kit can be used for measuring the relative amounts of DYR1A in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on DYR1A.

Product Specifications

Synonyms

Dual specificity tyrosine-phosphorylation-regulated kinase 1A;2.7.12.1 ; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB; DYRK1A; DYRK, MNB, MNBH

Gene Name

DYRK1A

UniProt

Q13627

Reactivity

Human, Mouse, Rat

Tissue Specificity

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity) . Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity) .