TCOF1 Colorimetric Cell-Based ELISA
The TCOF1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TCOF1 protein expression profile in cells. The kit can be used for measuring the relative amounts of TCOF1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TCOF1.
Product Specifications
Synonyms
Treacle protein; Treacher Collins syndrome protein; TCOF1
Gene Name
TCOF1
UniProt
Q13428
Reactivity
Human, Mouse
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832) . Required for neural crest specification: following monoubiquitination by the BCR (KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832) .
Molecular Weight
152106 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Treacle protein
Subcellular Location
Nucleus, nucleolus.
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