CGK 2 Colorimetric Cell-Based ELISA

The CGK 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CGK 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of CGK 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CGK 2.

Product Specifications

Synonyms

CGMP-dependent protein kinase 2; cGK 2; cGK2;2.7.11.12; cGMP-dependent protein kinase II; cGKII; PRKG2; PRKGR2

Gene Name

PRKG2

UniProt

Q13237

Reactivity

Human, Mouse, Rat

Tissue Specificity

Highly concentrated in brain, lung and intestinal mucosa.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Crucial regulator of intestinal secretion and bone growth (By similarity) . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity) . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity) . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity) .