CREM Colorimetric Cell-Based ELISA

The CREM Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CREM protein expression profile in cells. The kit can be used for measuring the relative amounts of CREM in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CREM.

Product Specifications

Synonyms

CAMP-responsive element modulator; Inducible cAMP early repressor; ICER; CREM

Gene Name

CREM

UniProt

Q03060

Reactivity

Human, Mouse, Rat

Tissue Specificity

Expressed in testes (round spermatids) (at protein level) . Isoform 14 is the major activator form in testes.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550) .