DGKQ Colorimetric Cell-Based ELISA
The DGKQ Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor DGKQ protein expression profile in cells. The kit can be used for measuring the relative amounts of DGKQ in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on DGKQ.
Product Specifications
Synonyms
Diacylglycerol kinase theta; DAG kinase theta;2.7.1.107; Diglyceride kinase theta; DGK-theta; DGKQ; DAGK4
Gene Name
DGKQ
UniProt
P52824
Reactivity
Human
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) . May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity) . May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.
Molecular Weight
101155 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Diacylglycerol kinase theta
Subcellular Location
Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189) . Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189) . Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189) .
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