CKI-epsilon Colorimetric Cell-Based ELISA

The CKI-epsilon Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CKI-epsilon protein expression profile in cells. The kit can be used for measuring the relative amounts of CKI-epsilon in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CKI-epsilon.

Product Specifications

Synonyms

Casein kinase I isoform epsilon; CKI-epsilon; CKIe;2.7.11.1; CSNK1E

Gene Name

CSNK1E

UniProt

P49674

Reactivity

Human, Mouse

Tissue Specificity

Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.