CBX5 Colorimetric Cell-Based ELISA
The CBX5 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CBX5 protein expression profile in cells. The kit can be used for measuring the relative amounts of CBX5 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CBX5.
Product Specifications
Synonyms
Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha; CBX5; HP1A
Gene Name
CBX5
UniProt
P45973
Reactivity
Human, Mouse
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Molecular Weight
22225 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Chromobox protein homolog 5
Subcellular Location
Nucleus. Chromosome. Chromosome, centromere. Colocalizes with HNRNPU in the nucleus (PubMed:19617346) . Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
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