CALR Colorimetric Cell-Based ELISA
The CALR Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CALR protein expression profile in cells. The kit can be used for measuring the relative amounts of CALR in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CALR.
Product Specifications
Synonyms
Calreticulin; CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60; CALR; CRTC
Gene Name
CALR
UniProt
P27797
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity) .
Molecular Weight
48142 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Calreticulin
Subcellular Location
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038) . Associated with the lytic granules in the cytolytic T-lymphocytes.
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