MBD3 Colorimetric Cell-Based ELISA
The MBD3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MBD3 protein expression profile in cells. The kit can be used for measuring the relative amounts of MBD3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MBD3.
Product Specifications
Synonyms
Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3
Gene Name
MBD3
UniProt
O95983
Reactivity
Human, Mouse
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384) . Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro) . Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175) . Recruits histone deacetylases and DNA methyltransferases.
Molecular Weight
32844 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Methyl-CpG-binding domain protein 3
Subcellular Location
Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
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