CBX6 Colorimetric Cell-Based ELISA

The CBX6 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CBX6 protein expression profile in cells. The kit can be used for measuring the relative amounts of CBX6 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CBX6.

Product Specifications

Synonyms

Chromobox protein homolog 6; CBX6

Gene Name

CBX6

UniProt

O95503

Reactivity

Human, Mouse, Rat

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530) . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235) . Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity) . May have a PRC1-independent function in embryonic stem cells (By similarity) .

Molecular Weight

43898 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Chromobox protein homolog 6

Subcellular Location

Nucleus. Chromosome. Uniformely distributed in the nucleoplasm (PubMed:18927235) . Localizes to the inactivated X chromosome in females (By similarity) .