ADA2L Colorimetric Cell-Based ELISA
The ADA2L Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ADA2L protein expression profile in cells. The kit can be used for measuring the relative amounts of ADA2L in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ADA2L.
Product Specifications
Synonyms
Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein; TADA2A; TADA2L; KL04P
Gene Name
TADA2A
UniProt
O75478
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity) . Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376) . May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376) .
Molecular Weight
51506 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Transcriptional adapter 2-alpha
Subcellular Location
Nucleus. Chromosome.
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