Dyskerin Colorimetric Cell-Based ELISA
The Dyskerin Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Dyskerin protein expression profile in cells. The kit can be used for measuring the relative amounts of Dyskerin in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Dyskerin.
Product Specifications
Synonyms
H/ACA ribonucleoprotein complex subunit DKC1;5.4.99.- ; CBF5 homolog; Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1; DKC1 ; NOLA4
Gene Name
DKC1
UniProt
O60832
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitously expressed.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674) . This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674) . Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674) . Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534) .
Molecular Weight
57674 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
H/ACA ribonucleoprotein complex subunit DKC1
Subcellular Location
Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies (coiled bodies) .
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