AKAP10 Colorimetric Cell-Based ELISA
The AKAP10 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor AKAP10 protein expression profile in cells. The kit can be used for measuring the relative amounts of AKAP10 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on AKAP10.
Product Specifications
Synonyms
A-kinase anchor protein 10, mitochondrial; AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10; AKAP10
Gene Name
AKAP10
UniProt
O43572
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity) .
Molecular Weight
73818 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
A-kinase anchor protein 10, mitochondrial
Subcellular Location
Mitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.
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