XRCC4 Colorimetric Cell-Based ELISA Kit
The XRCC4 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor XRCC4 protein expression profile in cells. The kit can be used for measuring the relative amounts of XRCC4 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on XRCC4.
Product Specifications
Synonyms
DNA repair protein XRCC4; X-ray repair cross-complementing protein 4; XRCC4
Gene Name
XRCC4
UniProt
Q13426
Reactivity
Human
Tissue Specificity
Widely expressed.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. Binds to DNA and to DNA ligase IV (LIG4) . The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Molecular Weight
38287 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
DNA repair protein XRCC4
Subcellular Location
Nucleus.
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