WWOX Colorimetric Cell-Based ELISA Kit
The WWOX Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor WWOX protein expression profile in cells. The kit can be used for measuring the relative amounts of WWOX in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on WWOX.
Product Specifications
Synonyms
WW domain-containing oxidoreductase;1.1.1.-; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1; WWOX; FOR, SDR41C1, WOX1
Gene Name
WWOX
UniProt
Q9NZC7
Reactivity
Human, Mouse
Tissue Specificity
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity) . May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF) -mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Molecular Weight
46677 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
WW domain-containing oxidoreductase
Subcellular Location
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus. Partially localizes to the mitochondria (PubMed:14695174) . Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity) . Translocates to the nucleus in response to TGFB1 (PubMed:19366691) . Isoform 5 and isoform 6 may localize in the nucleus.
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