WASP Colorimetric Cell-Based ELISA Kit
The WASP Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor WASP protein expression profile in cells. The kit can be used for measuring the relative amounts of WASP in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on WASP.
Product Specifications
Synonyms
Wiskott-Aldrich syndrome protein; WASp; WAS; IMD2
Gene Name
WAS
UniProt
P42768
Reactivity
Human, Mouse
Tissue Specificity
Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905) . Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905) . Possible regulator of lymphocyte and platelet function (PubMed:9405671) . Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809) . In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068) . Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947) .
Molecular Weight
52913 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Wiskott-Aldrich syndrome protein
Subcellular Location
Cytoplasm, cytoskeleton. Nucleus.
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