TEBP Colorimetric Cell-Based ELISA Kit
The TEBP Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor TEBP protein expression profile in cells. The kit can be used for measuring the relative amounts of TEBP in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on TEBP.
Product Specifications
Synonyms
Prostaglandin E synthase 3;5.3.99.3 ; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23; PTGES3; P23, TEBP
Gene Name
PTGES3
UniProt
Q15185
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419) . Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448) .
Molecular Weight
18697 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Prostaglandin E synthase 3
Subcellular Location
Cytoplasm.
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