SHP-2 Colorimetric Cell-Based ELISA Kit
The SHP-2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2.
Product Specifications
Synonyms
Tyrosine-protein phosphatase non-receptor type 11;3.1.3.48 ; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3; PTPN11; PTP2C, SHPTP2
Gene Name
PTPN11
UniProt
Q06124
Reactivity
Human, Mouse, Rat
Tissue Specificity
Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .
Molecular Weight
68436 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein phosphatase non-receptor type 11
Subcellular Location
Cytoplasm. Nucleus.
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