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PTP1B Colorimetric Cell-Based ELISA Kit

The PTP1B Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PTP1B protein expression profile in cells. The kit can be used for measuring the relative amounts of PTP1B in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PTP1B.

Product Specifications

Synonyms

Tyrosine-protein phosphatase non-receptor type 1;3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; PTP1B

Gene Name

PTPN1

UniProt

P18031

Reactivity

Human, Mouse, Rat

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

Molecular Weight

49967 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Tyrosine-protein phosphatase non-receptor type 1

Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane.

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