Proteasome alpha3 Colorimetric Cell-Based ELISA Kit
The Proteasome alpha3 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Proteasome alpha3 protein expression profile in cells. The kit can be used for measuring the relative amounts of Proteasome alpha3 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Proteasome alpha3.
Product Specifications
Synonyms
26S proteasome regulatory subunit 6A;26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1; PSMC3; TBP1
Gene Name
PSMC3
UniProt
P17980
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Molecular Weight
49204 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
26S proteasome regulatory subunit 6A
Subcellular Location
Cytoplasm. Nucleus. Colocalizes with TRIM5 in the cytoplasmic bodies.
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