PEA-15 Colorimetric Cell-Based ELISA Kit
The PEA-15 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor PEA-15 protein expression profile in cells. The kit can be used for measuring the relative amounts of PEA-15 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on PEA-15.
Product Specifications
Synonyms
Astrocytic phosphoprotein PEA-15;15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED; PEA15
Gene Name
PEA15
UniProt
Q15121
Reactivity
Human, Mouse, Rat
Tissue Specificity
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity) . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Molecular Weight
15040 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Astrocytic phosphoprotein PEA-15
Subcellular Location
Cytoplasm. Associated with microtubules.
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