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Patched Colorimetric Cell-Based ELISA Kit

The Patched Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Patched protein expression profile in cells. The kit can be used for measuring the relative amounts of Patched in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Patched.

Product Specifications

Synonyms

Protein patched homolog 1; PTC; PTC1; PTCH1; PTCH

Gene Name

PTCH1

UniProt

Q13635

Reactivity

Human, Mouse

Tissue Specificity

In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH) . Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Molecular Weight

160545 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Protein patched homolog 1

Subcellular Location

Cell membrane; Multi-pass membrane protein.

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