P73 Colorimetric Cell-Based ELISA Kit

The p73 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p73 protein expression profile in cells. The kit can be used for measuring the relative amounts of p73 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p73.

Product Specifications

Synonyms

Tumor protein p73; p53-like transcription factor; p53-related protein; TP73; P73

Gene Name

TP73

UniProt

O15350

Reactivity

Human

Tissue Specificity

Expressed in striatal neurons of patients with Huntington disease (at protein level) . Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.