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P62 Dok Colorimetric Cell-Based ELISA Kit

The p62 Dok Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor p62 Dok protein expression profile in cells. The kit can be used for measuring the relative amounts of p62 Dok in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on p62 Dok.

Product Specifications

Synonyms

Docking protein 1; Downstream of tyrosine kinase 1; p62 (dok) ; pp62; DOK1

Gene Name

DOK1

UniProt

Q99704

Reactivity

Human, Mouse, Rat

Tissue Specificity

Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

Applications

ELISA

Detection Range

> 5000 cells/well

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Molecular Weight

52392 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

Docking protein 1

Subcellular Location

Isoform 1: Cytoplasm. Nucleus.

Frequently Asked Questions

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