Recombinant Human Mn Superoxide Dismutase
Recombinant Human Mn Superoxide Dismutase
Product Specifications
Product Name Alternative
rHuMnSOD (SOD2)
Gene Name
SOD2
UniProt
P04179
Cellular Locus
Mitochondrion matrix.
Reactivity
Human
Target Antigen
Superoxide dismutase [Mn], mitochondrial
Target
Mn Superoxide Dismutase
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:10334867}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at -20°C for longer periods of time. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid multiple freeze-thaw cycles.
Product Datasheet
https://www.qedbio.com/wp-content/uploads/pdf/13003P.pdf
Specificity
Mn Superoxide Dismutase
Formulation
Sterile-filtered solution in 20mM Tris-HCl, pH 8.0, 20% glycerol.
Buffer pH
pH 8.0
Target Background
SOD2 is part of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. SOD2 destroys radicals which are usually produced within the cells and which are toxic to biological systems.
CAS Number
9000-83-3
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