Recombinant Human Mn Superoxide Dismutase

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

rHuMnSOD (SOD2)

Gene Name

SOD2

UniProt

P04179

Cellular Locus

Mitochondrion matrix.

Reactivity

Human

Target Antigen

Superoxide dismutase [Mn], mitochondrial

Target

Mn Superoxide Dismutase

Type

Protein

Applications

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Form

Liquid

Buffer

20 mM Tris

Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:10334867}.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store at -20°C for longer periods of time. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid multiple freeze-thaw cycles.

Specificity

Mn Superoxide Dismutase

Formulation

Sterile-filtered solution in 20mM Tris-HCl, pH 8.0, 20% glycerol.

Buffer pH

pH 8.0

Target Background

SOD2 is part of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. SOD2 destroys radicals which are usually produced within the cells and which are toxic to biological systems.