MMP-19 Colorimetric Cell-Based ELISA Kit

The MMP-19 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MMP-19 protein expression profile in cells. The kit can be used for measuring the relative amounts of MMP-19 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MMP-19.

Product Specifications

Synonyms

Matrix metalloproteinase-19; MMP-19; Matrix metalloproteinase RASI; MMP-18; MMP19; MMP18; RASI

Gene Name

MMP19

UniProt

Q99542

Reactivity

Human, Mouse

Tissue Specificity

Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941) .

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease) . May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.