MMP-16 Colorimetric Cell-Based ELISA Kit

The MMP-16 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MMP-16 protein expression profile in cells. The kit can be used for measuring the relative amounts of MMP-16 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MMP-16.

Product Specifications

Synonyms

MMP-X2; MMPX2; MT-MMP 3; MT-MMP2; MT-MMP3; MT3-MMP; MT3MMP; MTMMP3; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase

Gene Name

MMP16 C8orf57 , MMPX2

UniProt

P51512

Reactivity

Human, Mouse, Rat

Tissue Specificity

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.